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KMID : 0545120180280081332
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Journal of Microbiology and Biotechnology
2018 Volume.28 No. 8 p.1332 ~ p.1338
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Anti-Angiogenesis Effects Induced by Octaminomycins A and B against HUVECs
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Jang Jun-Pil
Han Jang-Mi
Jung Hye-Jin
Osada Hiroyuki
Jang Jae-Hyuk
Ahn Jong-Seog
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Abstract
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In the course of studies to discover natural products with anti-angiogenic properties, two cyclic octapeptides, octaminomycins A (1) and B (2), were isolated from the cultures of Streptomyces sp. RK85-270. Octaminomycins suppressed the vascular endothelial growth factor (VEGF)-induced proliferation, adhesion, tube formation, migration, and invasion of HUVECs. Anti-angiogenic activity was futher confirmed in vivo by the chicken chorioallantoic membrane assay. We also identified that 1 and 2 inhibited the phosphorylation of VEGF receptor 2, AKT, and ERK1/2 and the expression and activities of MMP-2 and MMP-9. These results suggest that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to angiogenesis-dependent diseases.
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KEYWORD
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Octaminomycin, anti-angiogenesis, HUVEC, VEGF, secondary metabolites
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